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Context, anatomy, and key evidence

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neuropeptide / GnRH regulator

Kisspeptin

Published evidence · coverage incomplete
Anatomical contextAnatomy connections are not mapped yet.

No body region is highlighted until this profile has a supported anatomical connection. This does not mean the peptide has no biological effects.

Read published mechanism findings ↓

At a glance

What is it—and why does it matter?

In ChEMBL, kisspeptin is indexed under the identifier CHEMBL4650403. Immunohistochemical analysis identified hypothalamic neurons that express Kiss2 in pejerrey, indicating central expression in the brain region associated with neuroendocrine control.

Sources for this introduction: [1] [2]

This published profile is a reference in progress. Findings retain their source context; missing topics are marked below.

What is it?

A molecule, not a product name.

Identity

In ChEMBL, kisspeptin is indexed under the identifier CHEMBL4650403.

Sources[1]chembl-moleculeKISSPEPTINChEMBL ID: CHEMBL4650403[1]chembl-moleculeKISSPEPTINPreferred name: KISSPEPTIN[1]chembl-moleculeKISSPEPTINMolecule type: Unknown[1]chembl-moleculeKISSPEPTINKiss-1; Kiss-1 metastasis suppressor; Kisspeptin; Metastin[3]pubmedThe kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.The discovery of the neuropeptide kisspeptin (Kp) and its receptor has attracted considerable attention
Source records
5
Independent studies
2

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    “ChEMBL ID: CHEMBL4650403”

    KISSPEPTIN · Molecule identity

    chembl-molecule:chembl4650403:efbe13678f28:efbe13678f28
  2. supports · Source-backed record
    “Preferred name: KISSPEPTIN”

    KISSPEPTIN · Molecule identity

    chembl-molecule:chembl4650403:efbe13678f28:efbe13678f28
  3. supports · Source-backed record
    “Molecule type: Unknown”

    KISSPEPTIN · Molecule identity

    chembl-molecule:chembl4650403:efbe13678f28:efbe13678f28
  4. supports · Source-backed record
    “Kiss-1; Kiss-1 metastasis suppressor; Kisspeptin; Metastin”

    KISSPEPTIN · Synonyms

    chembl-molecule:chembl4650403:efbe13678f28:efbe13678f28
  5. supports · Source-backed record
    “The discovery of the neuropeptide kisspeptin (Kp) and its receptor has attracted considerable attention”

    The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54. · Abstract

    pubmed:42379494:36cb991d9155:36cb991d9155

Identity

Kisspeptin is described as a neuropeptide involved in regulating gonadotropin-releasing hormone (GnRH)-ergic neurons in mammals.

Sources[2]pubmedKisspeptin-2 stimulates testicular function in adult pejerrey (Odontesthes bonariensis): Does it act directly on the testes?Kisspeptin is a neuropeptide that regulates GnRHergic neurons in mammals;
Source records
1
Independent studies
1

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    “Kisspeptin is a neuropeptide that regulates GnRHergic neurons in mammals;”

    Kisspeptin-2 stimulates testicular function in adult pejerrey (Odontesthes bonariensis): Does it act directly on the testes? · Abstract

    pubmed:42364900:d6ac84874ddb:d6ac84874ddb

How does it work?

Target, response, and disposition.

Mechanism

Immunoreactivity for Kiss2 was observed in spermatogonia within the testis, indicating local testicular localization of Kiss2 signal.

Sources[2]pubmedKisspeptin-2 stimulates testicular function in adult pejerrey (Odontesthes bonariensis): Does it act directly on the testes?Notably, Kiss2 immunoreactivity was detected in the spermatogonia in the testis.
Source records
1
Independent studies
1

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    “Notably, Kiss2 immunoreactivity was detected in the spermatogonia in the testis.”

    Kisspeptin-2 stimulates testicular function in adult pejerrey (Odontesthes bonariensis): Does it act directly on the testes? · Abstract

    pubmed:42364900:d6ac84874ddb:d6ac84874ddb

Mechanism

Immunohistochemical analysis identified hypothalamic neurons that express Kiss2 in pejerrey, indicating central expression in the brain region associated with neuroendocrine control.

Sources[2]pubmedKisspeptin-2 stimulates testicular function in adult pejerrey (Odontesthes bonariensis): Does it act directly on the testes?Immunohistochemical analyses revealed the presence of Kiss2-expressing neurons in the hypothalamus,
Source records
1
Independent studies
1

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    “Immunohistochemical analyses revealed the presence of Kiss2-expressing neurons in the hypothalamus,”

    Kisspeptin-2 stimulates testicular function in adult pejerrey (Odontesthes bonariensis): Does it act directly on the testes? · Abstract

    pubmed:42364900:d6ac84874ddb:d6ac84874ddb

Mechanism

Cells expressing Kiss2 were identified in the proximal pars distalis (PPD) region of the pituitary gland by immunohistochemical methods.

Sources[2]pubmedKisspeptin-2 stimulates testicular function in adult pejerrey (Odontesthes bonariensis): Does it act directly on the testes?as well as Kiss2-expressing cells in the proximal pars distalis (PPD) of this gland.
Source records
1
Independent studies
1

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    “as well as Kiss2-expressing cells in the proximal pars distalis (PPD) of this gland.”

    Kisspeptin-2 stimulates testicular function in adult pejerrey (Odontesthes bonariensis): Does it act directly on the testes? · Abstract

    pubmed:42364900:d6ac84874ddb:d6ac84874ddb

What has been studied?

What the evidence says.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Risks and interactions

Risks, organized for scanning.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Products and regulatory status

Same ingredient. Different records.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Administration context

The practical clinical context.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Research status + gaps

What still needs better answers?

  • No publishable claim yet for: administration, contraindication, effect, interaction, regulatory, safety
  • 61 compiled claim(s) withheld by automated assurance: assurance_score_below_0.58 (52), assurance_score_below_0.72 (8), current_regulatory_source_required (9), extraction_ambiguity (36), high_risk_requires_regulatory_or_two_independent_sources (9), no_direct_support (59)

These are the limits of this profile, not an exhaustive list of scientific uncertainties.

References + discovery

Open the records yourself.

  1. KISSPEPTIN ↗

    chembl-molecule · published 2026-08-27 · retrieved 2026-08-27T19:16:08Z

  2. Kisspeptin-2 stimulates testicular function in adult pejerrey (Odontesthes bonariensis): Does it act directly on the testes? ↗

    pubmed · published 2026-09-01 · retrieved 2026-08-27T11:48:55Z

  3. The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54. ↗

    pubmed · published 2026-10-01 · retrieved 2026-08-27T11:48:55Z

Publication history and provenance

Version 5 · Automated assessment · 2026-08-28T12:18:09Z

d228d11a475fdb1a945d2b22999b3aaf32d98e82aae8ab445f5a4691db309792