At a glance
What is it—and why does it matter?
Humanin is described as a mitochondrial DNA–encoded peptide (a mitochondria-derived peptide).
Sources for this introduction: [1]
This published profile is a reference in progress. Findings retain their source context; missing topics are marked below.
What is it?
A molecule, not a product name.
Identity
Humanin is classified among mitochondrial-derived peptides, a group of peptides encoded by mitochondrial-origin sequences and discussed in relation to metabolic regulation.
- Source records
- 1
- Independent studies
- 1
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“Mitochondrial-derived peptides (MDPs), such as humanin and MOTS-c, play a role in regulating energy balance and cellular stress responses.”
Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review. · BACKGROUND
pubmed:42640735:ffcd622d7fe4:ffcd622d7fe4
Identity
Humanin is described as a mitochondrial DNA–encoded peptide (a mitochondria-derived peptide).
- Source records
- 1
- Independent studies
- 1
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“This study aimed to investigate the role and potential mechanism of the mitochondrial DNA encoded peptide Humanin (HN) in alleviating rotenone-induced neurotoxicity.”
Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway. · Abstract
pubmed:42041115:0151e87542f7:0151e87542f7
How does it work?
Target, response, and disposition.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
What has been studied?
What the evidence says.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Risks and interactions
Risks, organized for scanning.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Products and regulatory status
Same ingredient. Different records.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Administration context
The practical clinical context.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Research status + gaps
What still needs better answers?
- No publishable claim yet for: administration, contraindication, effect, interaction, mechanism, regulatory, safety
- 54 compiled claim(s) withheld by automated assurance: assurance_score_below_0.58 (47), assurance_score_below_0.72 (6), current_regulatory_source_required (5), extraction_ambiguity (39), high_risk_requires_regulatory_or_two_independent_sources (6), no_direct_support (52)
These are the limits of this profile, not an exhaustive list of scientific uncertainties.
References + discovery
Open the records yourself.
- Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway. ↗
pubmed · published 2026-08-01 · retrieved 2026-08-27T11:48:55Z
- Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review. ↗
pubmed · published 2026-08-25 · retrieved 2026-08-27T11:48:55Z
Publication history and provenance
Version 3 · Automated assessment · 2026-08-27T11:48:55Z
6e6573c36fb28d8a639b25cc7cf50a6364f9e95b4d87f3bd4911853f3b25fff4