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Context, anatomy, and key evidence

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TGF-beta superfamily protein

GDF-11

Published evidence · coverage incomplete
Anatomical contextAnatomy connections are not mapped yet.

No body region is highlighted until this profile has a supported anatomical connection. This does not mean the peptide has no biological effects.

Read published mechanism findings ↓

At a glance

What is it—and why does it matter?

Growth differentiation factor-11 (GDF-11) is classified within the transforming growth factor-β (TGF-β) superfamily. The study evaluated GDF-11 as one of the biomarkers intended to reflect regenerative signaling, measured in circulation and tissues in murine injury/senescence models.

Sources for this introduction: [1] [2]

This published profile is a reference in progress. Findings retain their source context; missing topics are marked below.

What is it?

A molecule, not a product name.

Identity

Growth differentiation factor-11 (GDF-11) is classified within the transforming growth factor-β (TGF-β) superfamily.

Sources[1]pubmedGrowth differentiation factor-11 stimulates human extravillous trophoblast cell invasion by upregulating Slug-mediated N-cadherin expression.Growth differentiation factor-11 (GDF-11), a member of the transforming growth factor-β (TGF-β) superfamily[3]pubmedGDF-11 triggers cold-induced browning and metabolic activation of adipose tissue.Growth differentiation factor 11 (GDF-11), a circulating member of the TGF-β superfamily
Source records
2
Independent studies
2

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    “Growth differentiation factor-11 (GDF-11), a member of the transforming growth factor-β (TGF-β) superfamily”

    Growth differentiation factor-11 stimulates human extravillous trophoblast cell invasion by upregulating Slug-mediated N-cadherin expression. · INTRODUCTION

    pubmed:42097099:7f62be3927e7:7f62be3927e7
  2. supports · Source-backed record
    “Growth differentiation factor 11 (GDF-11), a circulating member of the TGF-β superfamily”

    GDF-11 triggers cold-induced browning and metabolic activation of adipose tissue. · OBJECTIVES

    pubmed:42296290:3f173bf830e0:3f173bf830e0

How does it work?

Target, response, and disposition.

Mechanism

The study evaluated GDF-11 as one of the biomarkers intended to reflect regenerative signaling, measured in circulation and tissues in murine injury/senescence models.

Sources[2]pubmedSynergistic senolytic-regenerative therapy significantly extends healthspan and lifespan.Outcomes included biochemical and histologic indices of liver injury, circulating and tissue biomarkers of senescence (IL-11, YKL-40, IL-6, IL-23 R) and regeneration (Klotho, FGF-2, neo-VEGF, GDF-11),
Source records
1
Independent studies
1

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    “Outcomes included biochemical and histologic indices of liver injury, circulating and tissue biomarkers of senescence (IL-11, YKL-40, IL-6, IL-23 R) and regeneration (Klotho, FGF-2, neo-VEGF, GDF-11),”

    Synergistic senolytic-regenerative therapy significantly extends healthspan and lifespan. · METHODS

    pubmed:42260530:23c65e1dc958:23c65e1dc958

What has been studied?

What the evidence says.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Risks and interactions

Risks, organized for scanning.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Products and regulatory status

Same ingredient. Different records.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Administration context

The practical clinical context.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Research status + gaps

What still needs better answers?

  • No publishable claim yet for: administration, contraindication, effect, interaction, regulatory, safety
  • 44 compiled claim(s) withheld by automated assurance: assurance_score_below_0.58 (39), assurance_score_below_0.72 (4), current_regulatory_source_required (2), extraction_ambiguity (43), high_risk_requires_regulatory_or_two_independent_sources (5), no_direct_support (43)

These are the limits of this profile, not an exhaustive list of scientific uncertainties.

References + discovery

Open the records yourself.

  1. Growth differentiation factor-11 stimulates human extravillous trophoblast cell invasion by upregulating Slug-mediated N-cadherin expression. ↗

    pubmed · published 2026-06-24 · retrieved 2026-08-26T20:13:52Z

  2. Synergistic senolytic-regenerative therapy significantly extends healthspan and lifespan. ↗

    pubmed · published 2026-06-08 · retrieved 2026-08-26T20:13:52Z

  3. GDF-11 triggers cold-induced browning and metabolic activation of adipose tissue. ↗

    pubmed · published 2026-06-16 · retrieved 2026-08-26T20:13:52Z

Publication history and provenance

Version 2 · Automated assessment · 2026-08-26T20:13:52Z

09f36c7c5c4294fbac91c1d4861182e2c013b23beb45e55629b505bd8b2dc1e9