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dipeptide

Alanyl-Glutamine

Published evidence · coverage incomplete
Anatomical contextAnatomy connections are not mapped yet.

No body region is highlighted until this profile has a supported anatomical connection. This does not mean the peptide has no biological effects.

Read published mechanism findings ↓

At a glance

What is it—and why does it matter?

Alanyl-glutamine (Aln-Gln) is identified as a dipeptide compound. An EAET enzyme cloned from Bacillus pumilus has less than 30% sequence identity compared with other reported acyltransferases. Compared with the SBM50 diet, adding 1% alanyl-glutamine was associated with significantly higher final body weight, weight gain rate, and specific growth rate.

Sources for this introduction: [1] [2] [3]

This published profile is a reference in progress. Findings retain their source context; missing topics are marked below.

What is it?

A molecule, not a product name.

Identity

Alanyl-glutamine (Aln-Gln) is identified as a dipeptide compound.

Sources[3]pubmedAlanyl-Glutamine Dipeptide MitigatesE. coli-Induced Pathogenesis inHy-LineBrown Hens: Mechanistic Insights into Microbiome Modulation, Antioxidant Response, and Intestinal Integrity.Alanyl-glutamine (Aln-Gln) dipeptide
Source records
1
Independent studies
1

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    “Alanyl-glutamine (Aln-Gln) dipeptide”

    Alanyl-Glutamine Dipeptide MitigatesE. coli-Induced Pathogenesis inHy-LineBrown Hens: Mechanistic Insights into Microbiome Modulation, Antioxidant Response, and Intestinal Integrity. · Abstract

    pubmed:42589590:b25e0a311380:b25e0a311380

How does it work?

Target, response, and disposition.

Mechanism

An EAET enzyme cloned from Bacillus pumilus has less than 30% sequence identity compared with other reported acyltransferases.

Sources[1]pubmedEnhanced synthesis of alanyl-glutamine dipeptide via molecular modification and process optimization of α-amino acid ester acyltransferase EAET.We successfully cloned EAET from Bacillus pumilus, which exhibits low sequence identity (<30 %) compared to other reported acyltransferases (AETs).
Reported result
<30 %
Source records
1
Independent studies
1

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    “We successfully cloned EAET from Bacillus pumilus, which exhibits low sequence identity (<30 %) compared to other reported acyltransferases (AETs).”

    Enhanced synthesis of alanyl-glutamine dipeptide via molecular modification and process optimization of α-amino acid ester acyltransferase EAET. · Abstract

    pubmed:41033017:d8028e7ce057:d8028e7ce057

What has been studied?

What the evidence says.

Comparative evidence

Compared with the SBM50 diet, adding 1% alanyl-glutamine was associated with significantly higher final body weight, weight gain rate, and specific growth rate.

Sources[2]pubmedAlanyl-Glutamine Attenuates Soybean Meal-Induced Intestinal Dysfunction and Growth Retardation in Largemouth Bass (Micropterus salmoides).Results demonstrated that the SBM50 + 1% AG group exhibited markedly higher final body weight, weight gain rate, and specific growth rate compared to the SBM50 (p< 0.05).
Reported result
p< 0.05
Source records
1
Independent studies
1

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    “Results demonstrated that the SBM50 + 1% AG group exhibited markedly higher final body weight, weight gain rate, and specific growth rate compared to the SBM50 (p< 0.05).”

    Alanyl-Glutamine Attenuates Soybean Meal-Induced Intestinal Dysfunction and Growth Retardation in Largemouth Bass (Micropterus salmoides). · Abstract

    pubmed:41424695:bad9e9159697:bad9e9159697

Risks and interactions

Risks, organized for scanning.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Products and regulatory status

Same ingredient. Different records.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Administration context

The practical clinical context.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Research status + gaps

What still needs better answers?

  • No publishable claim yet for: administration, contraindication, effect, interaction, regulatory, safety
  • 104 compiled claim(s) withheld by automated assurance: assurance_score_below_0.58 (83), assurance_score_below_0.72 (19), current_regulatory_source_required (16), extraction_ambiguity (56), high_risk_requires_regulatory_or_two_independent_sources (21), no_direct_support (102), proposal_not_staged (2)

These are the limits of this profile, not an exhaustive list of scientific uncertainties.

References + discovery

Open the records yourself.

  1. Enhanced synthesis of alanyl-glutamine dipeptide via molecular modification and process optimization of α-amino acid ester acyltransferase EAET. ↗

    pubmed · published 2026-01-01 · retrieved 2026-08-25T22:30:24Z

  2. Alanyl-Glutamine Attenuates Soybean Meal-Induced Intestinal Dysfunction and Growth Retardation in Largemouth Bass (Micropterus salmoides). ↗

    pubmed · published 2025-01-01 · retrieved 2026-08-25T22:30:24Z

  3. Alanyl-Glutamine Dipeptide MitigatesE. coli-Induced Pathogenesis inHy-LineBrown Hens: Mechanistic Insights into Microbiome Modulation, Antioxidant Response, and Intestinal Integrity. ↗

    pubmed · published 2026-08-02 · retrieved 2026-08-25T22:30:24Z

Publication history and provenance

Version 4 · Automated assessment · 2026-08-25T22:30:24Z

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