At a glance
What is it—and why does it matter?
Syn-Ake is described as a synthetic peptide (i.e., not naturally occurring and produced by chemical synthesis). Molecular dynamics simulations over 50 ns indicated stable positioning of Syn-Ake within the active sites of MMP-13 and SIRT1 receptors.
Sources for this introduction: [1] [2]
This published profile is a reference in progress. Findings retain their source context; missing topics are marked below.
What is it?
A molecule, not a product name.
Identity
Syn-Ake is described as a synthetic peptide (i.e., not naturally occurring and produced by chemical synthesis).
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“This study aims to investigate the possible interactions of Syn-Ake, a synthetic peptide, with matrix metalloproteinases (MMPs) and Sirtuin 1 (SIRT1)”
Anti-aging activity of Syn-Ake peptide byin silicoapproaches andin vitrotests. · Abstract
pubmed:37349941:f1c04f4e3d73:f1c04f4e3d73
How does it work?
Target, response, and disposition.
Mechanism
The study used 50 ns molecular dynamics (MD) simulations to computationally predict binding interactions and stability of Syn-Ake with MMPs and SIRT1 in a dynamic system.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“Binding interaction and protein-ligand stability of Syn-Ake with MMPs and SIRT1 in a dynamic system were predicted by 50 ns molecular dynamic (MD) simulation studies.”
Anti-aging activity of Syn-Ake peptide byin silicoapproaches andin vitrotests. · Abstract
pubmed:37349941:f1c04f4e3d73:f1c04f4e3d73
Mechanism
Molecular dynamics simulations over 50 ns indicated stable positioning of Syn-Ake within the active sites of MMP-13 and SIRT1 receptors.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“The MD results showed that the Syn-Ake peptide remained stable in the active site of MMP-13 and SIRT1 receptors during 50 ns simulations.”
Anti-aging activity of Syn-Ake peptide byin silicoapproaches andin vitrotests. · Abstract
pubmed:37349941:f1c04f4e3d73:f1c04f4e3d73
What has been studied?
What the evidence says.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Risks and interactions
Risks, organized for scanning.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Products and regulatory status
Same ingredient. Different records.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Administration context
The practical clinical context.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Research status + gaps
What still needs better answers?
- No publishable claim yet for: administration, contraindication, effect, interaction, regulatory, safety
- 4 compiled claim(s) withheld by automated assurance: assurance_score_below_0.58 (3), assurance_score_below_0.72 (1), extraction_ambiguity (4), high_risk_requires_regulatory_or_two_independent_sources (1), no_direct_support (4)
These are the limits of this profile, not an exhaustive list of scientific uncertainties.
References + discovery
Open the records yourself.
- Anti-aging activity of Syn-Ake peptide byin silicoapproaches andin vitrotests. ↗
pubmed · published 2024-07-01 · retrieved 2026-09-04T22:24:59Z
Publication history and provenance
Version 2 · Automated assessment · 2026-09-04T22:24:59Z
db418efb9f1a9d27c8f05c8b43773325664254e477cd6cb94fe6172d159adbfa