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Context, anatomy, and key evidence

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tachykinin neuropeptide

Substance P

Published evidence · coverage incomplete

Anatomy in the research

Anatomy evidence is still being assembled.

These are anatomical mentions in cited research—not established treatment targets or proof of benefit in people.

This publication has no anatomy passages that meet our source-linking checks yet. Read the available findings ↓

General anatomy view only. No peptide-specific structures are highlighted.

At a glance

What is it—and why does it matter?

An introduction is not yet available. The findings below address specific research questions, not a complete account of this peptide.

This published profile is a reference in progress. Findings retain their source context; missing topics are marked below.

What is it?

A molecule, not a product name.

Identity

Substance P (SP) is an endogenous neuropeptide whose high-affinity endogenous receptor target is the neurokinin-1 receptor (NK1R).

Sources[1]pubmedSubstance P innervation of the nucleus accumbens mediates alcohol consumption following chronic social stress.The NK1R is the high affinity, endogenous target of the neuropeptide substance P (SP).
Source records
1
Independent studies
1

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    “The NK1R is the high affinity, endogenous target of the neuropeptide substance P (SP).”

    Substance P innervation of the nucleus accumbens mediates alcohol consumption following chronic social stress. · Abstract

    pubmed:42069332:044b060bbf3f:044b060bbf3f

How does it work?

Target, response, and disposition.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

What has been studied?

What the evidence says.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Risks and interactions

Risks, organized for scanning.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Products and regulatory status

Same ingredient. Different records.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Administration context

The practical clinical context.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Research status + gaps

What still needs better answers?

  • No publishable claim yet for: administration, contraindication, effect, interaction, mechanism, regulatory, safety
  • 44 compiled claim(s) withheld by automated assurance: assurance_score_below_0.58 (36), assurance_score_below_0.72 (7), current_regulatory_source_required (7), extraction_ambiguity (43), high_risk_requires_regulatory_or_two_independent_sources (6), no_direct_support (42)
  • A source-backed introductory overview is not yet available.

These are the limits of this profile, not an exhaustive list of scientific uncertainties.

References + discovery

Open the records yourself.

  1. Substance P innervation of the nucleus accumbens mediates alcohol consumption following chronic social stress. ↗

    pubmed · published 2026-09-01 · retrieved 2026-08-29T08:37:13Z

Publication history and provenance

Version 1 · Automated assessment · 2026-08-29T08:37:13Z

27b81aba65d7f50b9b19980e029c5ddf2d0212d68b3efb776b646e75b1400bf6