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Context, anatomy, and key evidence

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pituitary adenylate cyclase peptide

PACAP

Published evidence · coverage incomplete

Anatomy in the research

Anatomy evidence is still being assembled.

These are anatomical mentions in cited research—not established treatment targets or proof of benefit in people.

This publication has no anatomy passages that meet our source-linking checks yet. Read the available findings ↓

General anatomy view only. No peptide-specific structures are highlighted.

At a glance

What is it—and why does it matter?

An introduction is not yet available. The findings below address specific research questions, not a complete account of this peptide.

This published profile is a reference in progress. Findings retain their source context; missing topics are marked below.

What is it?

A molecule, not a product name.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

How does it work?

Target, response, and disposition.

Mechanism

The stated aim links PACAP (pituitary adenylate cyclase-activating polypeptide) signaling in the hippocampus to the hypothesized mechanism of YJ’s rapid antidepressant-like actions.

Sources[1]pubmedYueju pill exerts rapid antidepressant effects via sequential activation of hippocampal GLP-1 receptor and PACAP signaling in mice.This study aimed to investigate the rapid antidepressant-like effects of YJ and uncover the underlying mechanism involving hippocampal GLP-1 receptor (GLP-1r) and pituitary adenylate cyclase-activating polypeptide (PACAP) signaling.
Source records
1
Independent studies
1

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    “This study aimed to investigate the rapid antidepressant-like effects of YJ and uncover the underlying mechanism involving hippocampal GLP-1 receptor (GLP-1r) and pituitary adenylate cyclase-activating polypeptide (PACAP) signaling.”

    Yueju pill exerts rapid antidepressant effects via sequential activation of hippocampal GLP-1 receptor and PACAP signaling in mice. · AIM OF THE STUDY

    pubmed:42034172:0a9991ee441a:0a9991ee441a

What has been studied?

What the evidence says.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Risks and interactions

Risks, organized for scanning.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Products and regulatory status

Same ingredient. Different records.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Administration context

The practical clinical context.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Research status + gaps

What still needs better answers?

  • No publishable claim yet for: administration, contraindication, effect, identity, interaction, regulatory, safety
  • 37 compiled claim(s) withheld by automated assurance: assurance_score_below_0.58 (29), assurance_score_below_0.72 (8), current_regulatory_source_required (7), extraction_ambiguity (33), high_risk_requires_regulatory_or_two_independent_sources (8), no_direct_support (37)
  • A source-backed introductory overview is not yet available.

These are the limits of this profile, not an exhaustive list of scientific uncertainties.

References + discovery

Open the records yourself.

  1. Yueju pill exerts rapid antidepressant effects via sequential activation of hippocampal GLP-1 receptor and PACAP signaling in mice. ↗

    pubmed · published 2026-08-10 · retrieved 2026-08-28T12:35:21Z

Publication history and provenance

Version 1 · Automated assessment · 2026-08-28T12:35:21Z

2a37a4d8037ea24ed3ec64b3be207b3177852310c4be5ec9ebd877fece3c234a