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Context, anatomy, and key evidence

← Peptide library

alpha-MSH fragment

KPV

Published evidence · coverage incomplete

Anatomy in the research

Explore the structures studied.

These are anatomical mentions in cited research—not established treatment targets or proof of benefit in people.

Intestine · 1 cited passage(s)

Population: Population not specified in the source claim.

We found that KPV acts via PepT1 expressed in immune and intestinal epithelial cells.

Applies only to the source-defined population, formulation, dose, and assessment period.

Evidence relationship: supports

Read finding and source →
Liver · 1 cited passage(s)

Population: hepg2 cells

KPV also downregulated AKT phosphorylation, leading to inhibition of mTORC1 phosphorylation under hepatic steatosis conditions.

Applies only to the source-defined population, formulation, dose, and assessment period.

Evidence relationship: supports

Read finding and source →

At a glance

What is it—and why does it matter?

KPV is an endogenous tripeptide (Lysine-Proline-Valine) described as being derived from α-melanocyte-stimulating hormone. Based on the reported cellular findings, KPV was characterized as regulating lipogenic signaling with antioxidant activity.

Sources for this introduction: [1] [2]

This published profile is a reference in progress. Findings retain their source context; missing topics are marked below.

What is it?

A molecule, not a product name.

Identity

KPV is a three–amino acid peptide (Lysine–Proline–Valine) described as endogenous and derived from α-melanocyte-stimulating hormone.

Molecular / pharmacology evidence

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    This study examined the protective role of Lysine-Proline-Valine (KPV), an endogenous tripeptide derived from α-melanocyte-stimulating hormone

    Lysine-proline-valine peptide attenuates hepatic lipid accumulation through ROS-dependent regulation of the PPARγ pathway in HepG2 cells. · UNLABELLED

    pubmed:42064835:95a89fcd1956:95a89fcd1956

Identity

In this review, KPV is included under the α-MSH (alpha-melanocyte-stimulating hormone) category of host defense peptides.

Molecular / pharmacology evidence

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    alpha-melanocyte-stimulating hormone (α-MSH) (e.g. KPV)

    Host defense peptides as a new drug lead to a strategy for inflammatory bowel disease. · Abstract

    pubmed:41241376:9b214e916d89:9b214e916d89

Identity

In this source, KPV is categorized as a synthetic fragment within the broader group of peptides/peptide analogues discussed in sport and bodybuilding.

Molecular / pharmacology evidence

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    Marketed as more selective and ostensibly safer alternatives, peptides-including growth hormone secretagogues (e.g., Ipamorelin), growth hormone-releasing hormone analogues (e.g., CJC-1295, Sermorelin), and synthetic fragments (e.g., Frag 176-191, KPV)-are promoted for muscle growth, fat metabolism, recovery, and anti-inflammatory effects.

    A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review. · Abstract

    pubmed:41880199:39c6683290a1:39c6683290a1

Identity

KPV is identified as the tripeptide lysine-proline-valine.

Molecular / pharmacology evidence

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    lysine-proline-valine (KPV)

    NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development. · Abstract

    pubmed:40935835:eb98c3ac8765:eb98c3ac8765

Identity

KPV is described as a tripeptide derived from α-melanocyte stimulating hormone (α-MSH).

Human research · design must be checked

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    This study investigates the mechanism by which the α-melanocyte stimulating hormone-derived tripeptide, KPV,

    Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. · BACKGROUND/AIMS

    pubmed:22837805:ee49ae914e82:ee49ae914e82

Identity

KPV is an endogenous tripeptide (Lysine-Proline-Valine) described as being derived from α-melanocyte-stimulating hormone.

Molecular / pharmacology evidence

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    Lysine-Proline-Valine (KPV), an endogenous tripeptide derived from α-melanocyte-stimulating hormone

    KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling. · Abstract

    pubmed:42585803:fa3d6f8ca000:fa3d6f8ca000

How does it work?

Target, response, and disposition.

Mechanism

Mechanistically in this model, KPV decreased reactive oxygen species (ROS) generation and was linked to prevention of extracellular signal-regulated kinase activation.

Molecular / pharmacology evidence

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    Mechanistic analysis revealed that KPV reduced reactive oxygen species generation, thereby preventing activation of extracellular signal-regulated kinase.

    Lysine-proline-valine peptide attenuates hepatic lipid accumulation through ROS-dependent regulation of the PPARγ pathway in HepG2 cells. · UNLABELLED

    pubmed:42064835:95a89fcd1956:95a89fcd1956

Mechanism

Mechanistically, KPV’s observed effect correlated with KPV entering the nucleus, stabilising IκBα, and suppressing nuclear translocation of YFP-tagged p65RelA.

Human research · design must be checked

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    The KPV effect was associated with its nuclear import, IκBα stabilisation and suppressed nuclear translocation of YFP-tagged p65RelA.

    Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. · RESULTS

    pubmed:22837805:ee49ae914e82:ee49ae914e82

Mechanism

In the reported steatosis conditions, KPV decreased AKT phosphorylation and was linked to inhibition of mTORC1 phosphorylation.

Molecular / pharmacology evidence

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    KPV also downregulated AKT phosphorylation, leading to inhibition of mTORC1 phosphorylation under hepatic steatosis conditions.

    Lysine-proline-valine peptide attenuates hepatic lipid accumulation through ROS-dependent regulation of the PPARγ pathway in HepG2 cells. · UNLABELLED

    pubmed:42064835:95a89fcd1956:95a89fcd1956

Mechanism

In airway epithelium, KPV is stated to suppress NFκB signalling via inhibition of p65RelA nuclear import.

Human research · design must be checked

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    KPV and γMSH respectively suppress NFκB signalling in airway epithelium by: i) inhibition of p65RelA nuclear import

    Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. · CONCLUSION

    pubmed:22837805:ee49ae914e82:ee49ae914e82

Mechanism

Based on the reported cellular findings, KPV was characterized as regulating lipogenic signaling with antioxidant activity.

Molecular / pharmacology evidence

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    These findings suggest that KPV acts as an effective antioxidant regulator of lipogenic signaling

    Lysine-proline-valine peptide attenuates hepatic lipid accumulation through ROS-dependent regulation of the PPARγ pathway in HepG2 cells. · UNLABELLED

    pubmed:42064835:95a89fcd1956:95a89fcd1956

Mechanism

The study assessed how KPV affects NFκB signaling induced by TNFα and rhino syncitial virus (RSV) in the 16HBE14o- immortalised human bronchial epithelial cell line.

Animal / laboratory evidence

1 cited source · Study independence not established

Animal or laboratory findings do not establish benefit or safety in people.

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    TNFα and rhino syncitial virus (RSV)-evoked nuclear factor-κB (NFκB) signaling was measured in immortalised human bronchial epithelial cells (16HBE14o-) in response to KPV and γMSH.

    Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. · METHODS

    pubmed:22837805:ee49ae914e82:ee49ae914e82

Mechanism

The SIPPC platform is described as a prodrug-conjugate system for oral delivery that includes PEG for hydrophilicity, a ROS-responsive self-immolative hydrophobic module for inflammation-triggered behavior, and a hydrolyzable scaffold; together these components enable spontaneous micelle-like nanoparticle assembly.

Molecular / pharmacology evidence

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    Here, we propose a self-immolative peptide prodrug conjugate (SIPPC) platform for inflammation-targeted oral delivery, integrating a hydrophilic polyethylene glycol segment, a reactive oxygen species (ROS)-responsive hydrophobic self-immolative module, and a hydrolyzable scaffold, which collectively enable spontaneous assembly into micelle-like nanoparticles.

    Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers. · Abstract

    pubmed:41533788:1159f2f92387:1159f2f92387

What has been studied?

What the evidence says.

Study findings

In an in vitro HepG2 steatosis model induced by oleic acid, KPV at 100 µg/mL significantly attenuated lipid accumulation.

Animal / laboratory evidence

1 cited source · Study independence not established

Animal or laboratory findings do not establish benefit or safety in people.

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    Treatment with KPV (100 µg/mL) significantly attenuated OA-induced lipid accumulation

    Lysine-proline-valine peptide attenuates hepatic lipid accumulation through ROS-dependent regulation of the PPARγ pathway in HepG2 cells. · UNLABELLED

    pubmed:42064835:95a89fcd1956:95a89fcd1956

Study findings

KPV showed dose-dependent inhibitory effects on NFκB signaling, matrix metalloproteinase-9 activity, and chemokine secretion (IL8 and eotaxin).

Human research · design must be checked

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    KPV and γMSH evoked a dose-dependent inhibition of NFκB, matrix metalloproteinase-9 activity, IL8 and eotaxin secretion.

    Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. · RESULTS

    pubmed:22837805:ee49ae914e82:ee49ae914e82

Study findings

The abstract reports that orally administered proKPV accumulated in inflamed lung tissue and produced potent anti-inflammatory effects in a mouse acute lung injury model (no quantitative values provided).

Animal / laboratory evidence

1 cited source · Study independence not established

Animal or laboratory findings do not establish benefit or safety in people.

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.

Exact passages, locators, and provenance
  1. supports · Source-backed record
    Beyond therapeutic effects in the colitis model, oral proKPV substantially accumulated in inflamed lungs and exhibited potent anti-inflammatory efficacy in mice with acute lung injury.

    Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers. · Abstract

    pubmed:41533788:1159f2f92387:1159f2f92387

Risks and interactions

Risks, organized for scanning.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Products and regulatory status

Same ingredient. Different records.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Administration context

The practical clinical context.

This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.

Additional research & classification gaps

11 archived statements are kept separate from drug-effect findings. Media studies, economic models, methods, and records with unresolved scope are not used as medical-effect evidence.

Inspect contextual research (11)
Research context · scope unclassified

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

The authors stated that their findings suggest KPV may be a therapeutic candidate for attenuating hepatocellular steatosis (a suggestion, not a demonstrated clinical effect).

Research context only—not evidence of a treatment effect.

Research context · scope unclassified

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

In an oleic-acid–treated HepG2 cell model, KPV at 100 µg/mL suppressed expression of fatty acid synthase (FAS), a lipogenesis-related enzyme.

Research context only—not evidence of a treatment effect.

Research context · scope unclassified

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

KPV is reported to have anti-inflammatory activity.

Research context only—not evidence of a treatment effect.

Research context · scope unclassified

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

KPV was reported to decrease the expression of key adipogenic markers, including PPARγ and FAS, during adipocyte differentiation.

Research context only—not evidence of a treatment effect.

Research context · scope unclassified

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

Using anti-inflammatory peptides (including KPV), the engineered SIPPC conjugates are reported to resist GI degradation, traverse mucus, and release payload in a ROS-responsive manner at inflamed tissue sites.

Research context only—not evidence of a treatment effect.

Research context · scope unclassified

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

KPV is a tripeptide composed of the amino acids Lys-Pro-Val.

Research context only—not evidence of a treatment effect.

Research context · scope unclassified

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

In the study background, KPV’s anti-inflammatory mechanism is described as not yet known.

Research context only—not evidence of a treatment effect.

Research context · scope unclassified

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

KPV was reported to attenuate ROS production during adipocyte differentiation, consistent with modulation of oxidative signaling.

Research context only—not evidence of a treatment effect.

Research context · scope unclassified

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

The study concludes that PepT1 functions as a transporter enabling cellular uptake of KPV.

Research context only—not evidence of a treatment effect.

Research context · scope unclassified

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

The reported regulatory effect of KPV was accompanied by suppression of fatty acid synthase (FAS) expression.

Research context only—not evidence of a treatment effect.

Research context · scope unclassified

1 cited source · Study independence not established

How to read this evidence

Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.

1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.

The results state that KPV’s activity is mediated through PepT1 in immune cells and intestinal epithelial cells.

Research context only—not evidence of a treatment effect.

Research status + gaps

What still needs better answers?

  • No publishable claim yet for: administration, contraindication, interaction, regulatory, safety
  • 50 compiled claim(s) withheld by automated assurance: assurance_score_below_0.58 (33), assurance_score_below_0.72 (7), current_regulatory_source_required (10), extraction_ambiguity (50), high_risk_requires_regulatory_or_two_independent_sources (12), no_direct_support (40), proposal_not_staged (2)

These are the limits of this profile, not an exhaustive list of scientific uncertainties.

References + discovery

Open the records yourself.

  1. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.

    pubmed · published 2008-01-01 · retrieved 2026-09-04T19:34:25Z

  2. Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists.

    pubmed · published 2012-01-01 · retrieved 2026-09-09T18:02:40Z

  3. NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development.

    pubmed · published 2026-02-01 · retrieved 2026-08-27T11:48:55Z

  4. Host defense peptides as a new drug lead to a strategy for inflammatory bowel disease.

    pubmed · published 2025-12-01 · retrieved 2026-08-27T11:48:55Z

  5. Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers.

    pubmed · published 2026-01-16 · retrieved 2026-08-27T11:48:55Z

  6. A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review.

    pubmed · published 2026-07-01 · retrieved 2026-08-26T08:42:26Z

  7. Lysine-proline-valine peptide attenuates hepatic lipid accumulation through ROS-dependent regulation of the PPARγ pathway in HepG2 cells.

    pubmed · published 2026-06-01 · retrieved 2026-08-27T11:48:55Z

  8. KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling.

    pubmed · published 2026-08-09 · retrieved 2026-08-27T11:48:55Z

Publication history and provenance

Version 2 · Automated assessment · 2026-09-09T18:02:40Z

201e396b5bcc0eacff99dcf2f0df25b49b8b95339304f6916dd07955a4e18e12