At a glance
What is it—and why does it matter?
Hexapeptide-11 is defined here as a hexapeptide composed of Phe-Val-Ala-Pro-Phe-Pro, abbreviated FVAPFP. The abstract indicates Hexapeptide-11 promotes greater nuclear localization/accumulation of Nrf2 in fibroblasts, consistent with activation of antioxidant-response signaling. The abstract reports that Hexapeptide-11 exposure activates (in a dose- and time-dependent manner) gene programs associated with proteasome function, autophagy, molecular chaperones, and antioxidant responses in fibroblasts.
Sources for this introduction: [1] [2] [3]
This published profile is a reference in progress. Findings retain their source context; missing topics are marked below.
What is it?
A molecule, not a product name.
Identity
Hexapeptide-11 is present in the formulation as a "saccharomyces/hexapeptide-11 ferment extract" ingredient.
1 cited source · 1 regulatory record
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“saccharomyces/hexapeptide-11 ferment extract (natural collagen builder)”
puristics™ totallyageless™ Daily Anti-Aging LotionDrug Facts · Principal Panel Display
dailymed:175c2f04-54d4-b2db-bc7b-416ffc425e21:aafd910c43c8:aafd910c43c8
Identity
The peptide source and preparation described are initial isolation from yeast extracts followed by solid state synthesis yielding high purity material.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“originally isolated from yeast extracts and later synthesized by solid state synthesis to high purity.”
Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts. · Abstract
pubmed:25974626:c8d01e3814e9:c8d01e3814e9
Identity
A peptide is defined here as a molecule with a minimum of two amino acids connected through peptide bonds.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“Peptides are molecules that consist of at least two amino acids linked by peptide bonds.”
Overview of Peptides and Their Potential Roles in Skin Health and Beauty · Abstract
doi:10.1002/psc.3668:b3e84740f53b:b3e84740f53b
Identity
Hexapeptide-11 appears in the product’s inactive ingredient list (i.e., it is present as an excipient/ingredient rather than the labeled active drug ingredient).
3 cited sources · 3 regulatory records
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
3 cited passages across 3 source records.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“water, butylene glycol dicaprylate/dicaprate, c12-15 alkyl benzoate, sodium hyaluronate, hydrolyzed potato protein, gamma aminobutyric acid, decamethylcyclopentasiloxane, polysilicone-15, c18-36 acid triglyceride, hexapeptide-11, silica, dipalmitoyl hydroxyproline, polyacrylate-13, hexanoyl dipeptide-3 norleucine acetate, thermus thermophillus ferment, uncaria tomentosa extract, porphyra umbilicalis extract, sodium tocopheryl phosphate, hydrolyzed vegetable protein, adenosine triphosphate, acetyl tyrosine, proline, sodium stearoyl glutamate, dimethicone, dimethiconol, cyclopentasiloxane, lecithin, sodium lactate, triethoxycaprylylsilane, cyclomethicone, peg-10 dimethicone, silica dimethyl silylate, glycerin, polyisobutene, polysorbate 20, phenoxyethanol, caprylyl glycol, butylene glycol, citric acid, xantham gum, hexylene glycol, disodium edta, methicone, alcohol, eugenol”
Stop the Clock Broad Spectrum SPF 50 · Inactive ingredients
dailymed:1725b5af-fe03-4372-beaf-d6fd9088a1f1:64cafe6e856b:64cafe6e856b - supports · Source-backed record
“Water, Mineral Oil, Petrolatum, Glycerin, Behentrimonium Methosulfate, Dimethicone, Stearyl Alcohol, Cetyl alcohol, Theobroma Grandiflorum Seed Butter, Oleth-20, Butylene Glycol, Saccharum Officinarum (Sugar Cane) Extract, Citrus Medica Limonum (Lemon) Fruit Extract, Betaine, Hexylene Glycol, Pyrus Malus (Apple) Fruit Extract, Camellia Sinensis Leaf Extract, Hexapeptide-11, Stearyl Dhydroxypropyldimonium Oligosaccharides, Allantoin, Silk Amino Acids, Panthenol, Menthyl Lactate, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Sorbitan Trioleate, Propylene Glycol, Diazolidinyl Urea, Methylparaben, Propylparaben, Sodium Sulfate, Fragrance.”
Doo Gro Anti-Dandruff Cream Vitalizer · Inactive Ingredients
dailymed:7366c6f8-4cc2-520e-e053-2991aa0a2cc8:9398b76aef40:9398b76aef40 - supports · Source-backed record
“Water/Aqua/Eau, Glycerin, Annona Cherimola Fruit Extract, Jojoba Oil/Macadamia Seed Oil Esters, Cetearyl Alcohol, Glyceryl Stearate, Cetearyl Olivate, Coco-Caprylate/Caprate, Sorbitan Olivate, Squalane, Helianthus Annuus (Sunflower) Seed Oil, Butyrospermum Parkii (Shea) Butter, Octyldodecanol, Triheptanoin, Allantoin, Zinc Oxide, Squalene, Helianthus Annuus (Sunflower) Seed Wax, Phytosteryl Macadamiate, Phytosterols, Lecithin, Acetyl Glutamine, Castanea Sativa (Chestnut) Leaf Extract, Ceramide NP, Amylopectin, Chlorophyllin-Copper Complex, Phytosphingosine, Ceramide AP, Cholesterol, Folic Acid, Hexapeptide-11, Oligopeptide-1, Oligopeptide-2, Bacillus/Soybean Ferment Extract, Sodium Hyaluronate, Oligopeptide-3, Tocopherol, Lithothamnion Calcareum Extract, Ceramide EOP, Carbomer, Sodium Stearoyl Glutamate, C9-12 Alkane, Polyurethane-100, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Caprylic/Capric Triglyceride, Sodium Lauroyl Lactylate, Sodium Hydroxide, Sodium Citrate, Propanediol, Polyhydroxystearic Acid, Pentylene Glycol, Sodium Dehydroacetate, Phenylpropanol, Citric Acid, Xanthan Gum, Lactic Acid, Sodium Carbonate, Sodium Chloride, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol.”
ECZEMA DERMATITIS RELIEF BALM · INACTIVE INGREDIENTS
dailymed:fb801d20-9bec-1c71-e053-6394a90a6e95:f4e76443ad68:f4e76443ad68
Identity
Hexapeptide-11 is defined here as a hexapeptide composed of Phe-Val-Ala-Pro-Phe-Pro, abbreviated FVAPFP.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“We have thus studied a hexapeptide (Hexapeptide-11) of structure Phe-Val-Ala-Pro-Phe-Pro (FVAPFP)”
Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts. · Abstract
pubmed:25974626:c8d01e3814e9:c8d01e3814e9
How does it work?
Target, response, and disposition.
Mechanism
The abstract indicates Hexapeptide-11 promotes greater nuclear localization/accumulation of Nrf2 in fibroblasts, consistent with activation of antioxidant-response signaling.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“Moreover, it promoted increased nuclear accumulation of Nrf2;”
Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts. · Abstract
pubmed:25974626:c8d01e3814e9:c8d01e3814e9
What has been studied?
What the evidence says.
Study findings
The abstract reports that Hexapeptide-11 exposure activates (in a dose- and time-dependent manner) gene programs associated with proteasome function, autophagy, molecular chaperones, and antioxidant responses in fibroblasts.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“Exposure of fibroblasts to Hexapeptide-11 promoted dose and time-dependent activation of proteasome, autophagy, chaperones and antioxidant responses related genes.”
Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts. · Abstract
pubmed:25974626:c8d01e3814e9:c8d01e3814e9
Study findings
The abstract reports a protective effect of Hexapeptide-11 in fibroblasts against oxidative-stress-mediated premature senescence.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“Hexapeptide-11 conferred significant protection in fibroblasts against oxidative-stress-mediated premature cellular senescence”
Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts. · Abstract
pubmed:25974626:c8d01e3814e9:c8d01e3814e9
Risks and interactions
Risks, organized for scanning.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Products and regulatory status
Same ingredient. Different records.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Administration context
The practical clinical context.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Research status + gaps
What still needs better answers?
- No publishable claim yet for: administration, contraindication, interaction, regulatory, safety
- 13 compiled claim(s) withheld by automated assurance: assurance_score_below_0.58 (10), assurance_score_below_0.72 (1), current_regulatory_source_required (1), extraction_ambiguity (15), high_risk_requires_regulatory_or_two_independent_sources (2), no_direct_support (11)
These are the limits of this profile, not an exhaustive list of scientific uncertainties.
References + discovery
Open the records yourself.
- Stop the Clock Broad Spectrum SPF 50 ↗
dailymed · published 2011-09-12 · retrieved 2026-09-04T19:33:58Z
- puristics™ totallyageless™ Daily Anti-Aging LotionDrug Facts ↗
dailymed · published 2011-02-07 · retrieved 2026-09-04T19:33:59Z
- Doo Gro Anti-Dandruff Cream Vitalizer ↗
dailymed · published 2023-10-31 · retrieved 2026-09-04T19:33:58Z
- ECZEMA DERMATITIS RELIEF BALM ↗
dailymed · published 2026-01-12 · retrieved 2026-09-04T19:33:59Z
- Overview of Peptides and Their Potential Roles in Skin Health and Beauty ↗
doi · published 2025-01-07 · retrieved 2026-09-04T19:33:59Z
- Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts. ↗
pubmed · published 2015-08-01 · retrieved 2026-09-04T19:33:59Z
Publication history and provenance
Version 2 · Automated assessment · 2026-09-04T19:33:59Z
86e427623e8101679ff13455dc06c6f83886856c4c0104172021155833d79621