At a glance
What is it—and why does it matter?
Epitalon is identified as a tetrapeptide composed of Ala, Glu, Asp, and Gly (AEDG), and is also referred to as Epithalon/Epithalone.
Sources for this introduction: [1]
This published profile is a reference in progress. Findings retain their source context; missing topics are marked below.
What is it?
A molecule, not a product name.
Identity
Epithalon is identified here as the synthetic tetrapeptide Ala-Glu-Asp-Gly.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“A threefold increase in nocturnal melatonin peaks occurs in old rhesus monkeys treated with a synthetic peptide Ala-Glu-Asp-Gly (Epithalon) designed basing on the amino acid content of a pineal peptide extract Epithalamin.”
[Aging of the pineal gland]. · Abstract
pubmed:12096440:4c5b903473bd:4c5b903473bd
Identity
Epitalon is identified as a tetrapeptide composed of Ala, Glu, Asp, and Gly (AEDG), and is also referred to as Epithalon/Epithalone.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide, Ala-Glu-Asp-Gly (AEDG),”
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. · Abstract
pubmed:40141333:e4ee56e216c4:e4ee56e216c4
How does it work?
Target, response, and disposition.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
What has been studied?
What the evidence says.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Risks and interactions
Risks, organized for scanning.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Products and regulatory status
Same ingredient. Different records.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Administration context
The practical clinical context.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Additional research & classification gaps
5 archived statements are kept separate from drug-effect findings. Media studies, economic models, methods, and records with unresolved scope are not used as medical-effect evidence.
Inspect contextual research (5)
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
In old rhesus monkeys, administering Epithalon (Ala-Glu-Asp-Gly) was reported to raise nocturnal melatonin peak levels by threefold.
Research context only—not evidence of a treatment effect.
- [Aging of the pineal gland].
A threefold increase in nocturnal melatonin peaks occurs in old rhesus monkeys treated with a synthetic peptide Ala-Glu-Asp-Gly (Epithalon) designed basing on the amino acid content of a pineal peptide extract Epithalamin.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
The authors contrast substantial biological/pharmacodynamic research with a limited quantity of physico-chemical and structural investigations of Epitalon.
Research context only—not evidence of a treatment effect.
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
the quantity of physico-chemical and structural investigations of this peptide remains quite limited.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
The abstract defines the paper’s purpose as a review that concludes major findings from studies and presents the current state of knowledge on Epitalon.
Research context only—not evidence of a treatment effect.
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
This review aims to conclude the most important findings from such studies, thus presenting the current state of knowledge on Epitalon.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
The abstract explicitly notes uncertainty about whether the described actions fully account for Epitalon’s mechanism(s) of action.
Research context only—not evidence of a treatment effect.
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
it remains uncertain whether these are the sole mechanisms of action of this compound.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
The abstract attributes Epitalone’s reported geroprotective/neuroendocrine effects to antioxidant, neuro-protective, and antimutagenic actions, arising from both specific and nonspecific mechanisms.
Research context only—not evidence of a treatment effect.
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
resulting from its antioxidant, neuro-protective, and antimutagenic effects, originating from both specific and nonspecific mechanisms.
Research status + gaps
What still needs better answers?
- No publishable claim yet for: administration, contraindication, interaction, regulatory, safety
- 13 compiled claim(s) withheld by automated assurance: assurance_score_below_0.58 (11), assurance_score_below_0.72 (1), current_regulatory_source_required (1), extraction_ambiguity (16), high_risk_requires_regulatory_or_two_independent_sources (1), no_direct_support (12)
These are the limits of this profile, not an exhaustive list of scientific uncertainties.
References + discovery
Open the records yourself.
- [Aging of the pineal gland]. ↗
pubmed · published 2002-01-01 · retrieved 2026-09-09T21:46:33Z
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. ↗
pubmed · published 2025-03-17 · retrieved 2026-09-09T18:02:17Z
Publication history and provenance
Version 2 · Automated assessment · 2026-09-09T21:46:33Z
3eb29d6c8d5851fdaa6309d91db52c8dceb5516c851c298a877a45c3822f578f