At a glance
What is it—and why does it matter?
Delta sleep-inducing peptide (DSIP) is defined here by the amino-acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. The investigation is described as double-blind and cross-over, with extensive psychophysiologic observations and measurements. In this study, DSIP was associated with a 59% increase in median total sleep time during the 130-min interval after treatment compared with placebo. In cultured human intestinal epithelial (Caco-2) monolayers, apical exposure to DSIP led to extensive metabolism over 2 hr, yielding tryptophan (Trp) predominantly and Trp-Ala to a lesser extent.
Sources for this introduction: [1] [2] [3] [4]
This published profile is a reference in progress. Findings retain their source context; missing topics are marked below.
What is it?
A molecule, not a product name.
Identity
The peptide later named DSIP was isolated from extracorporeal dialysate of cerebral venous blood in rabbits undergoing hypnogenic electrical stimulation of the intralaminar thalamic region, and was described as inducing slow-wave EEG after intraventricular infusion.
1 cited source · Study independence not established
Animal or laboratory findings do not establish benefit or safety in people.
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“A peptide which induces slow-wave EEG (sleep) after intraventricular infusion into the brain has been isolated from the extracorporeal dialysate of cerebral venous blood in rabbits submitted to hypnogenic electrical stimulation of the intralaminar thalamic area.”
The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide. · Abstract
pubmed:568769:626035fc39e6:626035fc39e6
Identity
DSIP (delta sleep-inducing peptide) is described as an isolated peptide whose characterized activity includes enhancing delta sleep in rabbits.
1 cited source · Study independence not established
Animal or laboratory findings do not establish benefit or safety in people.
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“Delta sleep-inducing peptide (DSIP) has been isolated and characterized by its capacity to enhance delta sleep in rabbits.”
Delta sleep-inducing peptide modulates the stimulation of rat pineal N-acetyltransferase activity by involving the alpha 1-adrenergic receptor. · Abstract
pubmed:3029331:19f0ff227b8d:19f0ff227b8d
Identity
Historically, DSIP was proposed as a candidate endogenous factor that could promote sleep.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“and initially regarded as a candidate sleep-promoting factor.”
Delta sleep-inducing peptide (DSIP): a still unresolved riddle. · Abstract
pubmed:16539679:92ffc612a115:92ffc612a115
Identity
Amino-acid analysis and sequencing identified DSIP as the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“It was shown by amino-acid analysis and sequence determination to be Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and named "Delta Sleep-Inducing Peptide" (DSIP).”
The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide. · Abstract
pubmed:568769:626035fc39e6:626035fc39e6
Identity
In animal experiments, delta-sleep-inducing-peptide (DSIP) was characterized as a neuropeptide.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“Animal experiments confirmed the neuropeptide nature of delta-sleep-inducing-peptide (DSIP) and a species-specific sleep promotion.”
Effects of DSIP in man. Multifunctional psychophysiological properties besides induction of natural sleep. · Abstract
pubmed:6689058:eee79228edfb:eee79228edfb
Identity
DSIP is reported to have been first isolated (1977) from rabbit cerebral venous blood by the Schoenenberger-Monnier group in Basel.
1 cited source · Study independence not established
Animal or laboratory findings do not establish benefit or safety in people.
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“Delta sleep-inducing peptide (DSIP) was isolated from rabbit cerebral venous blood by Schoenenberger-Monnier group from Basel in 1977”
Delta sleep-inducing peptide (DSIP): a still unresolved riddle. · Abstract
pubmed:16539679:92ffc612a115:92ffc612a115
Identity
DSIP is identified in this report as a synthetic “delta sleep-inducing peptide.”
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“DSIP (= synthetic delta sleep-inducing peptide)”
Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior. · Abstract
pubmed:6895513:be3f5f898415:be3f5f898415
Identity
The peptide referred to as Delta-Sleep-Inducing Peptide is denoted by the abbreviation DSIP.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“Delta-Sleep-Inducing Peptide (DSIP)”
DSIP--a tool for investigating the sleep onset mechanism: a review. · Abstract
pubmed:3286557:69c888c3254c:69c888c3254c
Identity
Delta sleep-inducing peptide (DSIP) is defined here by the amino-acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“A cultured human intestinal epithelial (Caco-2) cell monolayer was used to study the transport and metabolism of delta sleep-inducing peptide [DSIP (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu)].”
Transport and metabolism of delta sleep-inducing peptide in cultured human intestinal epithelial cell monolayers. · Abstract
pubmed:8689946:2628738eee26:2628738eee26
Identity
Beyond synthesizing DSIP, the authors also synthesized five possible metabolic products, two nonapeptide analogues (with one or two amino acids exchanged), and the related tripeptide Trp-Ser-Glu.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“This compound was synthesized as well as 5 possible metabolic products (1--8, 2--9, 2--8, 1--4 and 5--9), 2 nonapeptide analogues (with one and two amino-acids exchanged) and a related tripeptide (Trp-Ser-Glu).”
The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide. · Abstract
pubmed:568769:626035fc39e6:626035fc39e6
How does it work?
Target, response, and disposition.
Mechanism
The study quantified EEG signals from frontal neocortex and limbic archicortex via direct FFT processed on an 1108 computer system.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“The EEG from the frontal neocortex and the limbic archicortex were subjected to direct fast-Fourier transformation and analyzed by an 1108 computer system.”
The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide. · Abstract
pubmed:568769:626035fc39e6:626035fc39e6
Mechanism
The source notes proposed mechanisms for DSIP but states that convincing evidence supporting any proposed mechanism is lacking.
1 cited source · Study independence not established
Animal or laboratory findings do not establish benefit or safety in people.
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“Several mechanisms of action have been proposed, though no convincing evidence for any of them has been obtained so far.”
Delta sleep-inducing peptide modulates the stimulation of rat pineal N-acetyltransferase activity by involving the alpha 1-adrenergic receptor. · Abstract
pubmed:3029331:19f0ff227b8d:19f0ff227b8d
Mechanism
When DSIP was incubated with rat brain membrane, it underwent proteolytic degradation that liberated tryptophan, identified here as DSIP’s N-terminal amino acid.
1 cited source · Study independence not established
Animal or laboratory findings do not establish benefit or safety in people.
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“Incubation of DSIP with rat brain membrane resulted in the degradation of DSIP with liberation of tryptophan, an N-terminal amino acid of DSIP.”
Characterization of the release and metabolism of delta sleep-inducing peptide (DSIP) in the rat brain. · Abstract
pubmed:8474631:befeb0b0ea26:befeb0b0ea26
Mechanism
The investigation is described as double-blind and cross-over, with extensive psychophysiologic observations and measurements.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“under extensive psychophysiologic observations and measurements in a double-blind cross-over design.”
Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior. · Abstract
pubmed:6895513:be3f5f898415:be3f5f898415
Pharmacokinetics
In Caco-2 monolayers, basolateral DSIP exposure showed greater peptide stability over 2 hr while producing the same metabolite profile reported for apical exposure.
1 cited source · Study independence not established
Animal or laboratory findings do not establish benefit or safety in people.
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“When DSIP was added to the basolateral (BL) side of the monolayer, the same metabolites were detected, but the peptide was more stable (70.6 +/- 3.0% remaining after a 2-hr incubation).”
Transport and metabolism of delta sleep-inducing peptide in cultured human intestinal epithelial cell monolayers. · Abstract
pubmed:8689946:2628738eee26:2628738eee26
Pharmacokinetics
In cultured human intestinal epithelial (Caco-2) monolayers, apical exposure to DSIP led to extensive metabolism over 2 hr, yielding tryptophan (Trp) predominantly and Trp-Ala to a lesser extent.
1 cited source · Study independence not established
Animal or laboratory findings do not establish benefit or safety in people.
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“When applied to the apical (AP) side of Caco-2 cell monolayers, DSIP was rapidly metabolized (8.2 +/- 1.1% remaining after a 2-hr incubation), affording Trp as the major metabolite and Trp-Ala as a minor metabolite.”
Transport and metabolism of delta sleep-inducing peptide in cultured human intestinal epithelial cell monolayers. · Abstract
pubmed:8689946:2628738eee26:2628738eee26
What has been studied?
What the evidence says.
Study findings
Under in vitro conditions, DSIP (20–300 nM) significantly potentiated norepinephrine-induced NAT activity at 10(-6) M norepinephrine.
1 cited source · Study independence not established
Animal or laboratory findings do not establish benefit or safety in people.
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“DSIP in the range between 20 and 300 nM significantly enhanced NAT activity induced by 10(-6) M norepinephrine in vitro,”
Delta sleep-inducing peptide modulates the stimulation of rat pineal N-acetyltransferase activity by involving the alpha 1-adrenergic receptor. · Abstract
pubmed:3029331:19f0ff227b8d:19f0ff227b8d
Study findings
Polysomnography-based (objective) sleep outcomes suggested higher sleep efficiency in the DSIP group than in the placebo group.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“The results for objective sleep quality indicated higher sleep efficiency and shorter sleep latency with DSIP as compared to placebo.”
Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study. · Abstract
pubmed:1299794:4ad4c432640c:4ad4c432640c
Study findings
In rat pineal tissue, DSIP is reported to reduce the nocturnal rise in N-acetyltransferase (NAT) activity, with the magnitude depending on dose.
1 cited source · Study independence not established
Animal or laboratory findings do not establish benefit or safety in people.
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“We recently detected that DSIP reduced the nocturnal increase of N-acetyltransferase (NAT) activity in rat pineal in a dose-dependent manner.”
Delta sleep-inducing peptide modulates the stimulation of rat pineal N-acetyltransferase activity by involving the alpha 1-adrenergic receptor. · Abstract
pubmed:3029331:19f0ff227b8d:19f0ff227b8d
Study findings
In this study, DSIP was associated with a 59% increase in median total sleep time during the 130-min interval after treatment compared with placebo.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“sleep increased by 59% (median of total sleep time) within a 130-min interval after the treatment as compared with placebo.”
Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior. · Abstract
pubmed:6895513:be3f5f898415:be3f5f898415
Study findings
DSIP is reported to predominantly induce delta-sleep across rabbits, rats, mice, and humans.
1 cited source · Study independence not established
Animal or laboratory findings do not establish benefit or safety in people.
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“and to induce mainly delta-sleep in rabbits, rats, mice, and humans”
Delta-sleep-inducing peptide (DSIP): a review. · Abstract
pubmed:6145137:b573feb6a21b:b573feb6a21b
Study findings
In a rabbit model, intraventricular DSIP was reported to specifically enhance EEG delta and spindle activity.
1 cited source · Study independence not established
Animal or laboratory findings do not establish benefit or safety in people.
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“A highly specific delta and spindle EEG-enhancing effect of the synthetic DSIP could be demonstrated.”
The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide. · Abstract
pubmed:568769:626035fc39e6:626035fc39e6
Study findings
Compared with control conditions (CSF-like solution or other tested peptides), DSIP increased cortical EEG delta power by a mean of 35% in rabbits.
1 cited source · Study independence not established
Animal or laboratory findings do not establish benefit or safety in people.
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“The mean increase of EEG delta activity reached 35% in the neocortex and limbic cortex as compared to control animals receiving CSF-like solution or any of the other 8 peptides.”
The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide. · Abstract
pubmed:568769:626035fc39e6:626035fc39e6
Study findings
An acute subjective effect reported was an immediate feeling of sleep pressure following DSIP treatment.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“The subjects immediately reported a feeling of sleep pressure,”
Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior. · Abstract
pubmed:6895513:be3f5f898415:be3f5f898415
Study findings
In an open-label DSIP study in severe insomnia, investigators reported improvements in daytime mood and daytime performance.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Evidence boundary: Applies only to the source-defined population, formulation, dose, and assessment period.
Exact passages, locators, and provenance
- supports · Source-backed record
“The mood and performance during the daytime improved as well.”
A clinical trial with DSIP. · Abstract
pubmed:6391926:cad58528fdbb:cad58528fdbb
Risks and interactions
Risks, organized for scanning.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Products and regulatory status
Same ingredient. Different records.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Administration context
The practical clinical context.
This profile does not yet contain a published summary for this topic. This is a coverage gap, not evidence that no research exists.
Additional research & classification gaps
3 archived statements are kept separate from drug-effect findings. Media studies, economic models, methods, and records with unresolved scope are not used as medical-effect evidence.
Inspect contextual research (3)
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Despite being studied, DSIP’s endogenous presence and its biological activities are described as not well understood.
Research context only—not evidence of a treatment effect.
- Delta sleep-inducing peptide (DSIP): a still unresolved riddle.
its natural occurrence and biological activity still remains obscure.
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
Beyond sleep-related activity, DSIP is described as producing multiple physiological effects.
Research context only—not evidence of a treatment effect.
- DSIP--a tool for investigating the sleep onset mechanism: a review.
has several physiological effects in addition to its ability to promote sleep
1 cited source · Study independence not established
How to read this evidence
Sources and study IDs describe provenance, not clinical strength. Several articles can report the same study; one study can support several distinct findings. No clinical strength rating has been assigned here.
1 cited passage across 1 source record. 1 publication group(s) lack a resolved study identity.
According to the authors, evidence connecting DSIP to sleep remains insufficiently characterized, making the sleep-factor hypothesis poorly documented and weak.
Research context only—not evidence of a treatment effect.
- Delta sleep-inducing peptide (DSIP): a still unresolved riddle.
However, the link between DSIP and sleep has never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor. Thus the hypothesis regarding DSIP as a sleep factor is extremely poorly documented and still weak.
Research status + gaps
What still needs better answers?
- No publishable claim yet for: administration, contraindication, interaction, regulatory, safety
- 77 compiled claim(s) withheld by automated assurance: assurance_score_below_0.58 (56), assurance_score_below_0.72 (12), current_regulatory_source_required (14), extraction_ambiguity (65), high_risk_requires_regulatory_or_two_independent_sources (21), no_direct_support (64)
These are the limits of this profile, not an exhaustive list of scientific uncertainties.
References + discovery
Open the records yourself.
- Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study. ↗
pubmed · published 1992-01-01 · retrieved 2026-09-08T21:48:22Z
- Delta sleep-inducing peptide (DSIP): a still unresolved riddle. ↗
pubmed · published 2006-04-01 · retrieved 2026-09-04T19:33:14Z
- Delta sleep-inducing peptide modulates the stimulation of rat pineal N-acetyltransferase activity by involving the alpha 1-adrenergic receptor. ↗
pubmed · published 1987-04-01 · retrieved 2026-09-09T18:02:12Z
- DSIP--a tool for investigating the sleep onset mechanism: a review. ↗
pubmed · published 1988-02-01 · retrieved 2026-09-09T21:43:29Z
- The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide. ↗
pubmed · published 1978-09-06 · retrieved 2026-09-08T21:48:23Z
- Delta-sleep-inducing peptide (DSIP): a review. ↗
pubmed · published 1984-01-01 · retrieved 2026-09-09T21:43:28Z
- A clinical trial with DSIP. ↗
pubmed · published 1984-01-01 · retrieved 2026-09-04T19:33:15Z
- Effects of DSIP in man. Multifunctional psychophysiological properties besides induction of natural sleep. ↗
pubmed · published 1983-01-01 · retrieved 2026-09-09T18:02:12Z
- Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior. ↗
pubmed · published 1981-08-01 · retrieved 2026-09-04T19:33:13Z
- Characterization of the release and metabolism of delta sleep-inducing peptide (DSIP) in the rat brain. ↗
pubmed · published 1993-03-01 · retrieved 2026-09-09T21:43:31Z
- Transport and metabolism of delta sleep-inducing peptide in cultured human intestinal epithelial cell monolayers. ↗
pubmed · published 1995-12-01 · retrieved 2026-09-09T18:02:13Z
Publication history and provenance
Version 2 · Automated assessment · 2026-09-09T21:43:31Z
e52725f17c42a132571ffdc08071591584a3c6ddafb5c78651a20218b22400ff