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var(--mono);text-transform:uppercase;letter-spacing:.08em;grid-row:1/3}.reading-mode-bar>div:first-child p{color:#778187;margin:0;font-size:10px}.reading-mode-options{background:#ffffff59;border:1px solid #c4cac4;border-radius:999px;gap:4px;padding:4px;display:flex}.reading-mode-options button{color:#5d696e;min-height:34px;font:750 9px var(--mono);cursor:pointer;background:0 0;border:0;border-radius:999px;align-items:center;gap:7px;padding:0 13px;display:flex}.reading-mode-options button i{border:1px solid #89948f;border-radius:50%;width:6px;height:6px}.reading-mode-options button[aria-pressed=true]{color:#fff;background:#10202d}.reading-mode-options button[aria-pressed=true] i{border-color:var(--profile-accent);background:var(--profile-accent)}.mode-orientation{border-top:1px solid #ccd1cb;border-bottom:1px solid #ccd1cb;grid-template-columns:170px minmax(0,620px);gap:28px;width:min(1320px,100% - 64px);margin:28px auto 0;padding:16px 0;display:grid}.mode-orientation span{color:#53655e;font:750 8px var(--mono);text-transform:uppercase;letter-spacing:.08em}.mode-orientation p{color:#647178;margin:0;font-size:10px;line-height:1.6}.profile-v2-hero{padding-block:72px 92px}.profile-back{margin-bottom:58px}.profile-v2-intro{padding-block:72px 90px}.hero-source-links{flex-wrap:wrap;gap:7px;margin-top:27px;display:flex}.hero-source-links>a,.inline-citation{color:#315d84;width:max-content;font:750 8px/1.2 var(--mono);text-transform:uppercase;letter-spacing:.035em;vertical-align:middle;border:1px solid #bdc5bf;border-radius:999px;align-items:center;gap:5px;padding:5px 8px;display:inline-flex}.hero-source-links>a:hover,.inline-citation:hover{background:#ffffff80;border-color:#315d84}.inline-citation{margin:11px 0 0 8px}.profile-v2-intro .inline-citation{margin:15px 0 0}.profile-atlas{padding-block:90px}.profile-atlas-heading{margin-bottom:20px}.profile-atlas-stage{min-height:760px}.profile-atlas-stage .three-stage{height:760px}.product-list>a{border-right:1px solid #30404c;transition:background .2s;display:block}.product-list>a:last-child{border-right:0}.product-list>a:hover{background:#102432}.product-list article{border-right:0;flex-direction:column;display:flex}.product-list article b{color:var(--profile-accent);margin-top:auto;font-size:9px}.product-caution .inline-citation{color:#b8d9f4;border-color:#465966}.profile-mechanism dd .inline-citation{margin:14px 0 0;display:flex}.profile-atlas-note .inline-citation{margin:14px 0 0}.safety-columns>div{flex-direction:column;display:flex}.safety-columns .inline-citation{margin:auto 0 0}.evidence-v2-list .inline-citation{margin:14px 0 0}.boxed-warning .inline-citation{margin:14px 0 0;display:flex}.profile-v2[data-mode=simple] .profile-v2-dek{max-width:590px}.profile-v2[data-mode=simple] .profile-atlas-heading h2,.profile-v2[data-mode=simple] .safety-v2-heading h2{font-size:clamp(46px,5vw,70px)}@media (max-width:900px){.plex-menu-button{display:flex}.plex-header nav{z-index:80;color:#10202d;background:#f3f0e7;border-bottom:1px solid #aeb7b1;flex-direction:column;gap:0;padding:28px 24px 35px;display:none;position:fixed;top:77px;left:0;right:0;box-shadow:0 24px 60px #07101829}.plex-header.menu-open nav{display:flex}.plex-header nav a{font:400 26px var(--serif);text-transform:none;opacity:1;border-bottom:1px solid #ced2cc;justify-content:space-between;padding:17px 0}.plex-header.dark.menu-open .plex-wordmark,.plex-header.dark.menu-open .plex-menu-button{z-index:81;color:#10202d;position:relative}.plex-header.dark.menu-open:before{content:"";z-index:79;background:#f3f0e7;height:78px;position:fixed;top:0;left:0;right:0}.plex-principles>a,.plex-principles>a+a{border-right:0;min-height:250px;padding:28px 0}.reading-mode-bar{flex-direction:column;align-items:stretch;gap:10px;padding:12px 18px}.reading-mode-bar>div:first-child{display:none}.reading-mode-options{grid-template-columns:repeat(3,1fr);width:100%;display:grid}.reading-mode-options button{justify-content:center}.mode-orientation{grid-template-columns:1fr;gap:7px;width:calc(100% - 36px)}.product-list>a{border-bottom:1px solid #30404c;border-right:0}.product-list article{border-bottom:0}}@media (max-width:560px){.reading-mode-options button{padding-inline:7px;font-size:8px}.reading-mode-options button i{display:none}.profile-v2-hero{padding-top:50px}.profile-atlas{padding-top:65px}}@property --tw-blur{syntax:"*";inherits:false}@property --tw-brightness{syntax:"*";inherits:false}@property --tw-contrast{syntax:"*";inherits:false}@property --tw-grayscale{syntax:"*";inherits:false}@property --tw-hue-rotate{syntax:"*";inherits:false}@property --tw-invert{syntax:"*";inherits:false}@property --tw-opacity{syntax:"*";inherits:false}@property --tw-saturate{syntax:"*";inherits:false}@property --tw-sepia{syntax:"*";inherits:false}@property --tw-drop-shadow{syntax:"*";inherits:false}@property --tw-drop-shadow-color{syntax:"*";inherits:false}@property --tw-drop-shadow-alpha{syntax:"<percentage>";inherits:false;initial-value:100%}@property --tw-drop-shadow-size{syntax:"*";inherits:false}